Product name : Tyrocidin B
Synonyms : Tyrocidine;
CAS No. : 8011-61-8
Molecular Formula : C68H88N14O13
Molecular Weight : 1270.47628
Product description :
Tyrocidine is a mixture of cyclic decapeptides produced by the bacteria Bacillus brevis found in soil. It can be composed of 4 different amino acid sequences, giving tyrocidine A-D. (See figure 1). Tyrocidine is the major constituent of tyrothricin, which also contains gramicidin[1]. Tyrocidine was the first commercially available antibiotic, but has been found to be toxic toward human blood and reproductive cells. The function of tyrocidine within its host ‘’B. brevis’’ is thought to be regulation of sporulation .
Figure 1:a). Amino acid sequence of tyrocidine A. b). Sequence changes for the 4 types of tyrocidine.Tyrocidines A, B, and C are cyclic decapeptides. The biosynthesis of tyrocidine involves three enzymes. Parts of its sequence are identical to gramicidin S.